T − 6 h
Sympathetic tone climbs
Resting heart rate drifts above your own baseline while short-term HRV flattens — the earliest measurable sign of rising thyrotoxic drive.
ECG early warning · TPP
Two hours of warning, before the weakness sets in.
NuraSesne reads a single-lead ECG and follows the autonomic and electrical shifts that come before a thyrotoxic periodic paralysis episode — heart rate, HRV and QTc — so rising risk reaches you while there is still time to act.
- 1 ECG lead
- 15 min Feature window
- 2 h Warning horizon
Live monitor
Sample data
Heart rate
86bpm
+11 bpm
RMSSD
31ms
−16 ms
QTc
458ms
+24 ms
62%
2 h risk
Risk · next two hours
Elevated
Episode possible. Preventive guidance is ready in your care plan.
04:12 Baseline: personal 7-day Illustrative readings
Physiology
The body announces TPP before it arrives.
Thyroid hormone excess keeps the sympathetic nervous system in overdrive. As an episode approaches, that overdrive intensifies and potassium shifts into cells — changes that surface in heart rate, HRV and the QT interval hours before muscle weakness.
Modelled risk
QTc trend
Illustrative trends of expected signal behaviour. The dashed line marks the alert threshold two hours before an episode — not measured patient data.
T − 2 h
The electrical signature shifts
As potassium moves into cells, QTc lengthens and T waves flatten. The risk score crosses the threshold set with your clinician.
T − 0
Weakness begins
The episode you had two hours to prepare for — with guidance already in front of you and your care circle aware.
Signal path
From a raw heartbeat to a risk score.
Every number on this page comes from one sensor and one stream. Six stages, each with a single job.
01 — 06
Stage 01
One sensor, one waveform
A single-lead ECG sensor sits on the body and streams the raw electrical signal — P wave, QRS complex, T wave — sampled continuously and sent over Bluetooth or cable. No wearables, no derived step counts: just the heart's own electrical trace.
Single lead
Continuous stream
Raw waveform
Live derivation
samplingcontinuous
leadI · 1 channel
transportBLE / USB
Stage 02
Remove what the body adds
Raw ECG carries movement noise, 50 Hz mains interference and respiratory drift. A bandpass filter keeps the heart's band, a notch filter removes the power line, and baseline correction flattens the slow swing — leaving a waveform the next stage can trust.
0.5–40 Hz bandpass
50 Hz notch
Baseline correction
Live derivation
bandpass0.5–40 Hz
notch50 Hz
driftcorrected
Stage 03
Find every R peak
Pan-Tompkins style detection locates the apex of each QRS complex. The gap between consecutive peaks is the RR interval in milliseconds — the raw material for heart rate and every HRV metric that follows.
R-peak detection
RR intervals
Artifact rejection
Live derivation
R-peak0.41 s
RR interval812 ms
signal qualityclean
Stage 04
Turn intervals into physiology
HR is 60,000 divided by the mean RR interval. From the RR series come SDNN, RMSSD and the LF/HF ratio — a live picture of autonomic balance. From the waveform come QTc, T-wave amplitude and ST behaviour, the electrical signature of a potassium shift.
Heart rate
SDNN · RMSSD · LF/HF
QTc · T wave
Live derivation
HR86 bpm
RMSSD31 ms
QTc458 ms
Stage 05
Read the trend, not the snapshot
Each 15-minute window is compared with your own seven-day baseline over a six-hour lookback. An LSTM learns how those trends unfold in time; XGBoost combines the learned pattern with tabular triggers into a single risk score between 0 and 1.
15 min window
6 h lookback
LSTM + XGBoost
Live derivation
window15 min · 6 h
embeddingLSTM → embedding
score0.62
Stage 06
Two hours to act
When the score crosses the threshold agreed with your clinician, the alert arrives on screen and as a push notification: the risk, the features driving it, and the preventive steps already written into your care plan.
Push + on-screen
2 h horizon
Care-plan guidance
Live derivation
threshold0.60
alert issued04:12
windowT − 2 h
Personal baseline
Compared with you, not the population.
A resting heart rate of 86 bpm means something different for every patient. NuraSesne keeps a rolling seven-day baseline and scores your deviation from your own normal — then keeps learning as it settles.
- Heart rate Sympathetic drive and early drift above baseline
- RMSSD Short-term vagal tone; falls first under stress
- LF/HF ratio Balance between sympathetic and parasympathetic tone
- QTc Electrical fingerprint of a potassium shift
- T-wave amplitude Flattening or inversion as potassium falls
Feature window
Sample · 04:10
Resting HR7-day baseline 75 bpm
86 bpm
Elevated
RMSSD7-day baseline 47 ms
31 ms
Suppressed
LF/HF ratio7-day baseline 2.2
3.4
Shifted
QTc7-day baseline 434 ms
458 ms
Prolonged
T-wave amplitude7-day baseline 0.28 mV
0.12 mV
Flattening
Local timeEarly-morning window
04:10
Typical
Lookback 6 h · resolution 15 min · scored against personal baseline
Model
A slow signal needs a model with memory.
TPP precursors unfold over hours, not seconds. The LSTM holds that history; XGBoost turns it into a decision you and your clinician can inspect.
Input
6-hour trends
HR, HRV and QTc windows against your baseline
Stage one
LSTM
Learns how the hours before an episode unfold
Stage two
XGBoost
Weighs trends with tabular triggers and time of day
Output
Risk 0–1
Two-hour probability, thresholded with your clinician
Trend, not snapshot
The model reads the slope of heart rate, HRV and QTc — a single odd reading is not enough to raise an alert.
Explainable by design
Every alert can show which features pushed the score up, so you and your clinician can judge whether it makes sense.
Tuned with your clinician
Thresholds are set per patient and reviewed as your personal baseline settles, rather than fixed for everyone.
The warning
When risk crosses the line, the page changes.
At T−2 hours the monitor shifts from observation to guidance: what the score is, which signals are driving it, and the preventive steps already agreed with your clinician.
Alerts are probabilistic. They support your care plan; they do not replace emergency care or clinical judgement.
Elevated risk
04:12
62%
episode risk in the next two hours
QTc +24 ms
RMSSD −34%
HR +11 bpm
From your care plan
- Skip heavy carbohydrate meals
- Avoid strenuous activity
- Stay somewhere safe and seated
- Contact your clinician or take preventive medication as prescribed
Sample alert Care circle notified
Dashboard
One clinical view, from signal to history.
Live waveform, current vitals, the two-hour risk gauge and every past alert in one place — with your baseline learning quietly in the background.
Patient overview
Preview · sample
04:12
HR
86bpm
RMSSD
31ms
QTc
458ms
LF/HF
3.4
62%
2 h risk
Next two hours
Elevated
Preventive guidance is open in your care plan.
Alert history
12 Oct · 04:10
Elevated riskAlert sent to care circle
62%
Acknowledged
09 Oct · 03:22
WatchMonitoring, no alert raised
41%
Monitoring
04 Oct · 23:40
Elevated riskAlert sent to care circle
57%
Acknowledged
Sample · demo Step into the signed-in patient view.
Scope
An early-warning instrument, not a diagnosis.
01
One lead, one signal
A single-lead ECG sees rhythm and repolarisation, not everything. It is one input into your care, not a full cardiac workup.
02
Probabilities, not promises
A risk score expresses likelihood. It can rise without an episode and can miss one — your clinician's judgement always comes first.
03
Emergency care still applies
If you cannot move, collapse, or have trouble breathing, contact emergency services. Do not wait for an alert.
Keep two hours on your side.
Sign in to see your live signal, your personal baseline and who is on call.